Gut microbiome alterations are sex-dependently associated with brain abnormalities in a mouse model of Neurofibromatosis type I - Molecular Psychiatry
Nature
Last updated: April 27, 2026
This text details the acquisition and maintenance of genetically modified mice (Nf1+/-) for research purposes. These mice, specifically the B6.129S2-Nf1tm1Tyj/J strain, were obtained from The Jackson Laboratory and are a crucial component in studying the Nf1 gene.
- The Nf1+/- mice were procured from The Jackson Laboratory.
- These mice are characterized by a specific genetic modification: Nf1+/-.
- The full strain designation is B6.129S2-Nf1tm1Tyj/J.
- The original generation of these mice was performed by Jacks and colleagues.
- The mice are maintained on a C57BL6/J background.
- The primary purpose of these mice is likely for genetic research, given their specific genotype and origin from a reputable laboratory specializing in model organisms.
- The ongoing maintenance of these mice on a specific genetic background (C57BL6/J) ensures experimental consistency and reproducibility.
- The reference [22] suggests prior scientific publications detailing the creation and initial characterization of this mouse model.
- The source of the mice, The Jackson Laboratory, is a well-known provider of genetically engineered mouse models for biomedical research.
- The context implies a study focusing on the biological functions or disease implications related to the Nf1 gene, for which these mice serve as a preclinical model.
