Cognitive impairment preceding the onset of the first psychosis episode in schizophrenia - Molecular Psychiatry
Nature
Last updated: April 29, 2026
This meta-analysis examines cognitive deficits in individuals at ultra-high risk (UHR) for psychosis and those experiencing their first episode of psychosis (FEP). It investigates whether these deficits worsen during or after the onset of psychosis.
- Key Findings: Individuals at UHR for psychosis and those with FEP exhibit significant cognitive impairments across various domains.
- These domains include memory (verbal and visual), attention, executive functions (e.g., planning, problem-solving), and processing speed.
- The study found that cognitive deficits are present even before the onset of psychosis in the UHR group.
- Regarding the progression of deficits, the meta-analysis suggests that cognitive impairments generally do not worsen significantly during or immediately after the transition to FEP.
- However, some subtle changes or stabilization of existing deficits may occur.
- The findings highlight the importance of early identification and intervention for cognitive difficulties in individuals at risk of psychosis, as these issues are already established early in the illness trajectory.
- The consistency of deficits across UHR and FEP groups points to a stable underlying neurobiological process.
- Future research could explore specific interventions to mitigate these persistent cognitive challenges.
