Sex- and adipose depot-specific glucose metabolism following carbohydrate-enriched diets consumption with (un)interrupted prolonged sitting - Nutrition & Diabetes
Nature
Last updated: April 29, 2026
Research indicates that carbohydrate-rich diets and inactivity increase diabetes risk, particularly affecting glucose metabolism in abdominal (ASAT) and gluteal subcutaneous adipose tissues (GSAT). This study investigated how these factors influence glucose uptake and lipid metabolism in ASAT and GSAT. The findings highlight differences in how these fat depots respond to dietary and activity changes, offering insights into personalized diabetes prevention strategies.
- This study investigated the distinct roles of abdominal subcutaneous adipose tissue (ASAT) and gluteal subcutaneous adipose tissue (GSAT) in glucose metabolism when exposed to high-carbohydrate diets and reduced physical activity.
- ASAT exhibited a greater impairment in insulin sensitivity and glucose uptake compared to GSAT.
- High-carbohydrate diets led to increased de novo lipogenesis in ASAT.
- Sedentary behavior exacerbated insulin resistance in both adipose tissues, but ASAT was more susceptible to these negative effects.
- GSAT demonstrated a better capacity to store triglycerides and maintain glucose uptake even under metabolically challenging conditions.
- The study suggests that the differential metabolic plasticity between ASAT and GSAT influences overall glucose homeostasis.
- These findings underscore the importance of considering regional adipose tissue differences when developing interventions to prevent or manage type 2 diabetes.
- Targeting ASAT may be a more effective strategy for improving glucose metabolism and reducing diabetes risk.
